Histamine Digest - DAO Enzyme

Your body naturally produces the DAO enzyme, but various factors can lead to a deficiency or reduced activity, including genetics, certain medications, and gut health issues. A DAO supplement can help by providing the essential enzyme needed to break down excess dietary histamine in your small intestine. This helps to manage histamine levels and reduce the uncomfortable symptoms associated with histamine intolerance or ingesting high-histamine foods and beverages.

Histamine is found in many common foods, particularly those that are fermented, cured, or aged. Some of the most common high-histamine foods include:

• Aged cheeses 🧀
• Fermented foods (like sauerkraut, yogurt, and kombucha)
• Cured meats (salami, sausages)
• Alcoholic beverages (especially red wine and beer) 🍷
• Certain fruits and vegetables (like tomatoes, spinach, and avocados)

Dietary histamine refers to the histamine compound naturally present in foods and beverages, especially those that are aged, fermented, or cured. Environmental histamine, on the other hand, is produced by the body’s immune system in response to allergens and other triggers, such as pollen or dust. The key difference is that dietary histamine is ingested from external sources, while environmental histamine is produced internally.

Antihistamines work by blocking histamine receptors in your body, which can prevent the histamine from triggering a response. Our DAO supplement works differently. It provides the natural enzyme that breaks down and neutralizes histamine in your digestive tract before it can be absorbed into the bloodstream. This makes it a non-systemic approach that addresses the root cause of the histamine buildup without.

While some vegan Diamine Oxidase (DAO) supplements are available, they are typically derived from plant sources like pea sprouts. The DAO enzyme in OmneDiem’s Histamine Digest is sourced from porcine (pig) kidney protein extract, which has been shown in clinical studies to be a highly effective and stable source of the DAO enzyme. This animal-derived source is known to have a strong and effective histamine-degrading activity, which is crucial for delivering the best results to our customers. OmneDiem is committed to providing the most effective products, which is why we currently source our DAO from a porcine kidney. Our ongoing research and collaboration with manufacturers ensure we’re ready to transition to a plant-based alternative as soon as a stable and active source becomes available.

We recommend that you take Histamine Digest 15-20 minutes before high-histamine meals.

Histamine intolerance isn’t a true allergy, but a condition where your body has difficulty breaking down histamine from foods. This can happen if you have a deficiency or a lack of activity in the enzyme Diamine Oxidase (DAO), which is responsible for degrading histamine in your gut. When DAO isn’t working properly, histamine levels can build up, leading to symptoms that often mimic an allergic reaction.

The benefit of a porcine-sourced DAO product is that it is a well-studied and biologically active form of the enzyme. DAO from porcine kidney extract has been widely used in dietary supplements because it has been shown to effectively break down histamine. This source is recognized for its ability to support the healthy degradation of histamine in the digestive tract.

Symptoms of histamine intolerance vary widely, as histamine receptors are found throughout the body. Common symptoms can include digestive issues like bloating, cramps and diarrhea; skin reactions such as urticaria or flushing; and other symptoms like head discomfort, a stuffy or runny nose, and an irregular heartbeat. These symptoms typically appear shortly after consuming histamine-rich foods.