DAO Deficiency and Histamine Intolerance are real.
Histamine Digest® and the Histamine Digest Family of Products supply Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.*
OmneDiem® Histamine Digest® Supplements
Diamine oxidase (DAO Enzyme) supplements are taken to help break down excess histamine in the body, potentially alleviating symptoms of histamine intolerance. DAO is an enzyme that is naturally occurring in the human body and helps digest histamine, a compound released during histamine (allergic) reactions and by the body. DAO Supplementation can be used to manage symptoms associated with histamine intolerance.
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Histamine Digest DAO 30,000 HDU - Histamine Neutralizing Enzyme CSP
Regular price From $55.95 USDRegular priceUnit price / per$87.95 USDSale price From $55.95 USDSale -
Histamine Digest 360 - Mast Cell Support - DAO Enzyme & P5P Vitamin B6 - 120 DR Capsules CSP
Regular price $110.95 USDRegular priceUnit price / per$119.99 USDSale price $110.95 USDSale -
Drink HD - Diamine Oxidase (DAO Enzyme) CS
Regular price From $19.95 USDRegular priceUnit price / per$19.99 USDSale price From $19.95 USDSale
Omne Diem
Histamine Complete - Histamine Digest Seasonal Support & Dietary Histamine Support A
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Histamine Digest 360 - Mast Cell Support - DAO Enzyme & P5P Vitamin B6 - 120 DR Capsules CSP
4.3 / 5.0
(923) 923 total reviews
Regular price $110.95 USDRegular priceUnit price / per$119.99 USDSale price $110.95 USDSale -
Joint Comfort with ZOARA, 60 Capsules AP
3.3 / 5.0
(6) 6 total reviews
Regular price $54.95 USDRegular priceUnit price / per$59.99 USDSale price $54.95 USDSale -
Histamine Complete - Histamine Digest Seasonal Support & Dietary Histamine Support A
4.3 / 5.0
(38) 38 total reviews
Regular price From $39.99 USDRegular priceUnit price / per$49.99 USDSale price From $39.99 USDSale -
Brain Support with Cerenx and MecobalActive, 60 Capsules AP
4.2 / 5.0
(18) 18 total reviews
Regular price $54.95 USDRegular priceUnit price / per$59.99 USDSale price $54.95 USDSale

I’ve used other DAO supplements but none work as well as these. I highly recommend for anyone with histamine intolerance or MCAS. Can be one of the biggest gamechangers when dealing with these conditions.
Rachel Skocylas

This product is amazing! Both My Son and Wife use the product and its been a savior in our home. The product is CLEAN no triggering additives and works amazing. It has helped them with Mast cell and histamine flares and general tolerance. 100% recommend to anyone.
Jarrett Gelowitz

Please never stop making this product. It is the first and only DAO I can take with such intense allergies – and it’s been a life saver! Thank you!!
Emily
What to know about OmneDiem
OmneDiem® is a new kind of company for a new kind of healthcare that is headquartered in Ann Arbor, MI and includes an office in Harrisburg, NC. With a multi-channel approach in unique market positions, OmneDiem® is advancing integrative wellness strategies by providing consumers, healthcare practitioners, distributors and retailers with innovative dietary supplements that address under-served and emerging needs.
The primary focus of OmneDiem® lies in the field of digestive health, especially food intolerances. OmneDiem® provides unique solutions in the field of Histamine Intolerance (HIT). Our experience and expertise in this area started in 2000 when we began to develop and execute extensive clinical research in HIT.
In 2016, OmneDiem® launched with the introduction of the natural enzyme Diamine Oxidase (DAOgest®) as the exclusive provider of the effective dietary supplement for the management of HIT in the U.S. Accompanied by an extensive public education campaign, OmneDiem® became the first U.S. company to actively raise awareness of HIT while offering an exclusive and effective formula. OmneDiem® continues to invest in clinical research, education and product improvements to help bolster Histamine Digest®. The Histamine Digest® product line continues to provide the most effective support for HIT in the U.S.